I have a 2017 F250, here are some of the things I have found helpful.
I use this locking hitch receiver pin. It is coded to my truck key so I don’t have to carry extra keys. I also have a couple of padlocks and a cable lock for my generator. I’ve been using these for several years and they work great. They are easy to set up to your truck key, you just insert your key and turn it and it is permanently coded to your key.
https://www.amazon.com/BOLT-7023585-.../dp/B00OQPPO6K
As far as tool storage, I have a Weatherguard toolbox in the bed of the truck and I keep a decent amount of tools in there. All the basic stuff plus a socket set, impact wrench, electrical connections, straps, jack, first aid, torque wrench, etc.
This probably isn’t an issue for your 2016, but in 2017 and later models the spots on the receiver to attach the safety chains is difficult to use. They are too small. So I use two small shackles to attach the safety chains.
The tow/haul mode is a great feature to use when you are towing, it does a lot of the work for you. The tires which came with the truck should be adequate. You want to make sure they are at least load range E I believe.
Congratulations on your new truck!