You can, each individual tire bears it's own load so psi in one doesn't affect the others. However, the 10 ply will stand taller which may have an effect on the stance of your coach, suspension, and possibly load distribution. Not much, you may or may not be able to notice it. Personally, I'd change the 4th tire to a 10 ply as well and move your other one to the spare. That will give you an even stance and heat build up since all 4 will be working in harmony.
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Brent
2013 Alpine 3500RE
2019 Silverado 2500HD Duramax
U.S. Air Force Retired (25 yrs)
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