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Let's start with I-80 west to I-35 south to Joplin. I-44 west to Oklahoma City and then I-40 west for a long while. Probably at Flagstaff head south on I-17, however there will be a number of suggestions before this is over for alternate routes from Albuquerque. We have been that way many times, but the interstate follows the least mountainous regions. We prefer to come into Mesa (Apache Junction) from the east. It is all four lane, but very mountainous. Sure is beautiful however. Have a great trip however you travel.