My summer homebase is in South Fork, so I travel 149 frequently, in the truck or Harley. Its good, mostly smooth, 2 lane roadway with ocassional passing areas. the only area needing extra attention, is the down hill section from Slumgullion (11,530) down into Lake City. Its a pretty steep grade, but as long as you gear down & take it slow, no problems.
In the Fall, this section has some of the best colors. Here is a shot about half way down
